studing alzheimer's

Studying Alzheimer’s & Dementia

Part of the fear around Alzheimer’s stems from the sense that there’s nothing we can do about it. Despite decades of research and many books and literature written we still have no disease-modifying treatment and no cure. So, if we’re lucky enough to live long enough, Alzheimer’s appears to be our brain’s destiny. But maybe it doesn’t have to be. What if I told you we could change these statistics, literally change our brain’s destiny, without relying on a cure or advancements in medicine?

Let’s begin by looking at what we currently understand about the neuroscience of Alzheimer’s. The point of connection, this space circled in red, is called the synapse. The synapse is where neurotransmitters are released. This is where signals are transmitted, where communication happens. This is where we think, feel, see, hear, desire . . . and remember. And the synapse is where Alzheimer’s happens.

 

Many scientists believe that poor sleep hygiene might actually be a predictor of Alzheimer’s. A single night of sleep deprivation leads to an increase in amyloid beta.

 

During the business of communicating information, in addition to releasing neurotransmitters like glutamate into the synapse, neurons also release a small peptide called amyloid beta. Normally, amyloid beta is cleared away metabolized by microglia, the janitor cells of our brains. While the molecular causes of Alzheimer’s are still debated, most neuroscientists believe that the disease begins when amyloid beta begins to accumulate.

Too much is released, or not enough is cleared away, and the synapse begins to pile up with amyloid beta. And when this happens, it binds to itself, forming sticky aggregates called amyloid plaques.

This initial step into the disease, this presence of amyloid plaques accumulating, can already be found in your brains. The only way we could be sure of this would be through a PET scan because at this point, you are blissfully unaware. You’re not showing any impairments in memory, language, or cognition . . . yet.

We think it takes at least 15 to 20 years of amyloid plaque accumulation before it reaches a tipping point, then triggering a molecular cascade that causes the clinical symptoms of the disease. Prior to the tipping point, your lapses in memory might include things like, “Why did I come in this room?” or “Oh . . .  what’s his name?” or “Where did I put my keys?” These are all normal kinds of forgetting. In fact, I would argue that these examples might not even involve your memory, because you didn’t pay attention to where you put your keys in the first place. After the tipping point, the glitches in memory, language and cognition are different. Instead of eventually finding your keys in your coat pocket or on the table by the door, you find them in the refrigerator, or you find them and you think, “What are these for?”

So what happens when amyloid plaques accumulate to this tipping point? Our microglia janitor cells become hyper-activated, releasing chemicals that cause inflammation and cellular damage. We think they might actually start clearing away the synapses themselves. A crucial neural transport protein called “tau” becomes hyperphosphorylated and twists itself into something called “tangles,” which choke off the neurons from the inside. By mid-stage Alzheimer’s, we have massive inflammation and tangles and all-out war at the synapse and cell death. So if you were a scientist trying to cure this disease, at what point would you ideally want to intervene?

Many scientists are betting big on the simplest solution: keep amyloid plaques from reaching that tipping point, which means that drug discovery is largely focused on developing a compound that will prevent, eliminate, or reduce amyloid plaque accumulation. So the cure for Alzheimer’s will likely be preventative medicine. We’re going to have to take this pill before we reach that tipping point before the cascade is triggered, before we start leaving our keys in the refrigerator.alzheimers and dementia study

We think this is why, to date, these kinds of drugs have failed in clinical trials –not because the science wasn’t sound, but because the people in these trials were already symptomatic. It was too late. Think of amyloid plaques as a lit match. At the tipping point, the match sets fire to the forest. Once the forest is ablaze, it doesn’t do any good to blow out the match. You have to blow out the match before the forest catches fire.

Even before scientists’ sort this out, this information is really good news for us, because it turns out that the way we live can influence the accumulation of amyloid plaques. And so there are things we can do to keep us from reaching that tipping point. Let’s picture your risk of Alzheimer’s as a see-saw scale. We’re going to pile risk factors on one arm, and when that arm hits the floor, you are symptomatic and diagnosed with Alzheimer’s. Let’s imagine you’re 50 years old. You’re not a spring chicken anymore, so you’ve accumulated some amyloid plaques with age. Your scale is tipped a little bit.

Now let’s look at your DNA. We’ve all inherited our genes from our moms and our dads. Some of these genes will increase our risk and some will decrease it. If you’re like Alice in “Still Alice,”you’ve inherited a rare genetic mutation that cranks out amyloid beta, and this alone will tip your scale arm to the ground. But for most of us, the genes we inherit will only tip the arm a bit.

For example, APOE4 is a gene variant that increases amyloid, but you can inherit a copy of APOE4 from mom and dad and still never get Alzheimer’s, which means that for most of us, our DNA alone does not determine whether we get Alzheimer’s.

So what does? We can’t do anything about getting older or the genes we’ve inherited. So far, we haven’t changed our brain’s destiny. What about sleep? In slow-wave deep sleep, our glial cells rinse cerebral spinal fluid throughout our brains, clearing away metabolic waste that accumulated in our synapses while we were awake. Deep sleep is like a power cleanse for the brain. But what happens if you short change yourself on sleep? Many scientists believe that poor sleep hygiene might actually be a predictor of Alzheimer’s. A single night of sleep deprivation leads to an increase in amyloid beta. And amyloid accumulation has been shown to disrupt sleep, which in turn causes more amyloid to accumulate.

And so now we have this positive feedback loop that’s going to accelerate the tipping of that scale. What else? Cardiovascular health. High blood pressure, diabetes, obesity, smoking, high cholesterol, have all been shown to increase our risk of developing Alzheimer’s. Some autopsy studies have shown that as many as 80 percent of people with Alzheimer’s also had cardiovascular disease.

Aerobic exercise has been shown in many studies to decrease amyloid betain animal models of the disease. So a heart-healthy Mediterranean lifestyle and diet can help to counter the tipping of this scale. So there are many things we can do to prevent or delay the onset of Alzheimer’s

But if, despite all of this, you are someday diagnosed with Alzheimer’s, there are three lessons I’ve learned from my grandmother and the dozens of people I’ve come to know living with this disease. Diagnosis doesn’t mean you’re dying tomorrow. Keep living. You won’t lose your emotional memory. You’ll still be able to understand love and joy. You might not remember what I said five minutes ago, but you’ll remember how I made you feel. And you are more than what you can remember.

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